Abstract

Background: For the treatment of early glottic cancer (T1/T2N0M0), different treatment options, such as transoral laser microsurgery, open surgical techniques, and primary radiotherapy, are under discussion. In this context, the aim of the present study was to describe oncologic results and complication rates of transoral laser microsurgery in treatment of early glottic cancer.


 


Methods: A prospective cohort study in Ho Chi Minh City Ear Nose Throat Hospital included early stages (T1/T2N0M0) glottic cancer patients scheduled to undergo transoral laser microsurgery from January 2016 until June 2017. Data on demographics, site and extent of disease, treatment, complication and early outcome were collected and analyzed.


 


Results: Twenty eight early stages glottic cancer cases were exclusively treated by TLM and included into this study, 27 (96.4%) patients were male and 1 (3.6%) were female. The mean age was 61.8 years (± 8 years). 92.9% tumors is T1 and 7.1% for T2. The presence of intraoperative complications was low, affecting only 3.6% of patients. Immediate postoperative complications occurred in 7.1%, whereas delayed complications affected 10.7% of patients, without any of them being fatal. The most frequent complication of TLM was granulation tissue formation. 30% of patients had normal voices and a further 48% had only mild or moderate voice change. At their last follow up, no patients assessed had any difficulty swallowing relating to their treatment for glottic cancer.


 


Conclusion: TLM has shown good results and low complication rate compared with traditional open surgery during intervention, in the immediate and delayed postoperative period and in the long-term with respect to radiotherapy, and thus shows utility as a primary treatment modality for early glottic cancer.

Keywords: Cancer, Early glottic cancer, Early glottic carcinoma, Transoral laser microsurgery (TLM), Carbon dioxide laser, Organ preservation

References

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