ID: 1031 Synthesis of Polymeric Nanoparticles of α-mangostin and its Cytotoxicity to Human Cancer Cell Lines

Phuong T.M. Nguyen; Lam D. Tran; Nguyen K. Dang; Mai T. Tran; Anh V.T. Nguyen; Albert Bolhuis

doi:10.15419/bmrat.v4iS.307

Vol 4 No S (2017): Abstract Proceeding: International conference INNOVATIONS IN CANCER RESEARCH AND REGENERATIVE MEDICINE 2017 / S 106 Poster Abstract

ID: 1031 Synthesis of Polymeric Nanoparticles of α-mangostin and its Cytotoxicity to Human Cancer Cell Lines

Phuong T.M. Nguyen

Lam D. Tran

Nguyen K. Dang

Mai T. Tran

Anh V.T. Nguyen

Albert Bolhuis

More author's info

Phuong T.M. Nguyen
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam

[email protected]

Lam D. Tran
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam

Nguyen K. Dang
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam

Mai T. Tran
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam

Anh V.T. Nguyen
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam

Albert Bolhuis
Institute of Biotechnology, Vietnam Academy of Science and Technology, Ha Noi, VietNam

Submitted: Aug 31, 2017 | Published: Aug 31, 2017

Vol 4 No S (2017): Abstract Proceeding: International conference INNOVATIONS IN CANCER RESEARCH AND REGENERATIVE MEDICINE 2017 | DOI: 10.15419/bmrat.v4iS.307 | Page No.: S 106

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Nguyen, P., Tran, L., Dang, N., Tran, M., Nguyen, A., & Bolhuis, A. (2017). ID: 1031 Synthesis of Polymeric Nanoparticles of α-mangostin and its Cytotoxicity to Human Cancer Cell Lines. Biomedical Research and Therapy, 4(S), S 106. https://doi.org/10.15419/bmrat.v4iS.307

Copyrights: Phuong T.M. Nguyen, Lam D. Tran, Nguyen K. Dang, Mai T. Tran, Anh V.T. Nguyen, Albert Bolhuis, 2017. License:

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

α-Mangostin (AMG) extracted from Garcinia mangostana L., has potent anti-cancer properties, however its clinical application is limited due to poor aqueous-solubility. Here, we successfully synthesised and characterised water-soluble ß-cyclodextrin-coated AMG 30-50 nm-size nanoparticles (NMG). Similar cytotoxic activities against LU-1 (human lung adenocarcinoma) and HL-60 (human promyelocytic leukemia) cancer cells of water-soluble NMG and organic-solvent soluble AMG were found with IC50 of 8.86 and 9.86 µg/mL, respectively. The data demonstrates that the nanoparticles improve bioavailability while maintain anti-cancer activity of AMG.

Keywords: α-Mangostin ß-cyclodextrin Biology cytotoxicity cancer cells

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