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Toxoplasmosis Gondii Infection and Diabetes Mellitus Type 2 Treated by Using Autologous Peripheral Blood Stem Cells a Unique Case Report of a Caucasian 83 Year Old Lady

Ciro Gargiulo 1, *
Van Hung Pham 2
Kieu C.D. Nguyen 1
Ngan Duong Kim 1
Thinh Van Nguyen 1
An Tuan Luu 1
Kenji Abe 3
Melvin Shiffman 4
  1. Division of Internal Medicine, The Human Medicine International Clinic, Ho Chi Minh City, Vietnam
  2. Molecular Diagnostics Department, Nam Khoa-Biotek Laboratory, Ho Chi Minh City, Vietnam
  3. Department of Pathology, National Institute of Infectious Diseases, Tokyo
  4. Section of Surgery, Newport Specialty Hospital, Tustin, California, US
Correspondence to: Ciro Gargiulo, Division of Internal Medicine, The Human Medicine International Clinic, Ho Chi Minh City, Vietnam. Email: [email protected].
Volume & Issue: Vol. 2 No. 08 (2015) | Page No.: 339-346 |
Published: 2015-08-30

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This article is published with open access by BioMedPress. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. 

Abstract

Introduction

Toxoplasma gondii is an intracellular protozoan responsible for up to one-third of the world's population infestation. Diabetes is one of the most silent and threatening disease of the modern time it is constantly increasing in both industrialized and developing countries. This is a case of clinically importance for two reason, firstly it will help clinicians save a broad differential diagnosis when attending to evaluate analogous cases and secondly, it may confirm the role of autologous peripheral blood stem cells (PB-SCs) in enhancing auto-immune response against parasitic infection and in regulating insulin uptake in diabetes mellitus type 2 (DM2).

Case presentation

We present a unique case of 83-year-old woman from Argentina presenting with a widespread erythema and urticaria for 5 months and DM2 as underlying condition. She was initially diagnosed with unspecific skin auto-immune disorder. By the time of visit she was complaining of constant diarrhea-constipation and general mental and physical fatigue.

Conclusion

This case illustrates that toxoplasmosis can present with just simple disseminated and generalized skin erythema with severe itching and, thus can be confused with similar infectious disease such as Epstein-Barr virus (EBV), cytomegalovirus, cat scratch disease or leishmaniasis. The report emphasizes the need of correct diagnostic procedure in confusing cases, and may help to increase the awareness about the identification of this disease. This case may open to the possibility of a different approach and methodology in treatment T gondii and DM2 through the use of PB-SCs.

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